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Tris(3-hydroxypropyltriazolylmethyl)amine (THPTA), 5 mg

≥95 %, ROTI®Click Grade
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Examples of effect: Lead to damage to heath, cause irritation to eyes, skin or respiratory organs. Are fatal in larger quantities. Safety: As previously stated, in the event of skin irritation or contact with eyes, rinse with water or a suitable medium.
warning
H315-H319-H335
i causes skin irritation, causes serious eye irritation, may cause respiratory irritation
P280 P302+P352.0 P305+P351+P338 P332+P313 P337+P313
i wear protective gloves/protective clothing/eye protection/face protection, IF ON SKIN: Wash with plenty of water, IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing, if skin irritation occurs: Get medical advice/attention, if eye irritation persists: Get medical advice/attention
Pack Qty.
Pack.
THPTA
Empirical formula C18H30N10O3
Molar mass (M) 434,50 g/mol
Melting point (mp) 336 °C
Storage temp. -20 °C
Transport temp. cooled
WGK 1
CAS No. [760952-88-3]

Ligand for Click Chemistry
For a 0,1 M solution: add 230 l to 10 mg.

Type analysis

€34.95/Pack Qty. 

excl. VAT. | 5 mg per Pack Qty.

Art. No. 7822.1

In stock
24 hour direct shipment
from 6 Pack Qty. €33.20/Pack Qty.
from 24 Pack Qty. €31.46/Pack Qty.
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Technical Information
pKa (at 25 °C) ≥95 %  
Tris(3-hydroxypropyltriazolylmethyl)amine (THPTA)
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Order No. Pack Qty. Pack. Price Quantity
7822.1 5 mg plastic €34.95
7822.2 10 mg plastic €50.00
7822.3 50 mg plastic €85.90
7822.4 100 mg plastic €143.95
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General information

Tip:

TBTA (Art.No. 7814) is suitable as copper-stabilising ligand for reactions in organic solvents. THPTA (Art.No. 7822) on the other hand is an optimal ligand for reactions in aqueous media.

Reagents for Click Chemistry

Starting from diverse copper catalyst sources, over Cu(I) stabilising ligands to buffer additives and solvents, you will find all necessary reagents in the special ROTI®Click quality to perform your click reactions here.

Click Chemistry

The copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) is the most prominent example of a group of reactions named click reactions. According to Sharpless‘ definition, these reactions are characterised by high yields, mild reaction conditions, and by their tolerance of a broad range of functional groups.[1–3] Typically, the reactions require simple or no workup or purification of the product. The most important characteristic of the CuAAC reaction is its unique bioorthogonality as neither azide nor terminal alkyne functional groups are generally present in natural systems.

References:1 H. C. Kolb, M.G. Finn, K. B. Sharpless, Angew. Chem. Int. Ed. 2001, 40, 2004-2021.2 C.W. Tornoe, C. Christensen, M. Meldal, J. Org. Chem. 2002, 67, 3057-3064.3 V. V. Rostovtsev, L. G. Green, V. V. Fokin, K. B. Sharpless, Angew. Chem. 2002, 114, 2708-2711; Angew. Chem. Int. Ed. 2002, 41, 2596-2599.

Analysis certificates

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The following analysis certificates have been found:

Type analysis

Appearancewhite powder
Assay (HPLC)≥95 %
SolubilityH2O, DMSO/t-Butanol Solvent

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