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L-Azidolysine hydrochloride, 100 mg

From  baseclick
≥98 %
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H-L-Lys(N3)-OH · HCl, 6-Azido-L-lysine hydrochloride
Empirical formula C6H12N4O2 · HCl
Molar mass (M) 208,64 g/mol
Storage temp. +4 °C
Transport temp. cooled
WGK 1
CAS No. 159610-92-1

Unnatural azido-modified amino acids for monitoring protein synthesis
6-Azido-L-lysine HCl can be incorporated into proteins to study and monitor protein synthesis.
Due to the azide-moiety, this molecule allows for specific bioconjugation of various functionalities such as e.g. PEGs, antibodies or fluorescent labels, by click chemistry or Staudinger ligation.

€150.50/Pack Qty. 

excl. VAT. | 100 mg per Pack Qty.

Art. No. 7861.3

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Product details



L-Azidolysine hydrochloride ≥98 %

Technical Information
Alternative Name H-L-Lys(N3)-OH · HCl 
L-Azidolysine hydrochloride
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7861.3 100 mg plastic

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Downloads / MSDS

General information

Amino acids

Our amino acids are of the highest purity and suitable for a broad range of applications in biochemistry. Besides the natural occurring L-amino acids, we offer a selection of unnatural D-amino acids and DL-amino acids.


Azido Amino Acids

With the emergence of click chemistry the use of azide- and alkyne-derivatised α-amino acids has found high interest e.g. in the area of peptide synthesis as a powerful tool in the development of new therapeutics and biological chemistry fundamental research. Peptide labelling mostly requires reactions which are running close to physiological conditions (neutral pH, aqueous solution, ambient temperature). Cu(I)-catalysed alkyne-azide cycloaddition (CuAAC) is optimal for such biological compounds, here the advantages of click chemistry once again show their potential. The low reactant concentrations, low background labelling, the quantitative and rapid labelling, plus the mild reaction conditions fit the necessary reactivity, selectivity and biocompatibility criteria for the peptide labelling and thus ensure the preservation of biological function. Carl ROTH provides high quality azido amino acids. In this form they can easily undergo click reaction when an alkyne functional reporter molecule is present.


Click Chemistry

The copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) is the most prominent example of a group of reactions named click reactions. According to Sharpless’ definition, these reactions are characterised by high yields, mild reaction conditions, and by their tolerance of a broad range of functional groups.[1-3] Typically, the reactions require simple or no workup or purification of the product. The most important characteristic of the CuAAC reaction is its unique bioorthogonality as neither azide nor terminal alkyne functional groups are generally present in natural systems.


References:
1 H. C. Kolb, M.G. Finn, K. B. Sharpless, Angew. Chem. Int. Ed. 2001, 40, 2004-2021.
2 C.W. Tornoe, C. Christensen, M. Meldal, J. Org. Chem. 2002, 67, 3057-3064.
3 V. V. Rostovtsev, L. G. Green, V. V. Fokin, K. B. Sharpless, Angew. Chem. 2002, 114, 2708-2711; Angew. Chem. Int. Ed. 2002, 41, 2596-2599.


Click Chemistry

In recent years, click chemistry has become increasingly important and steadily more popular in research and development. The reasons for this are not only the easy handling and the high yields but also the countless application possibilities. Carl ROTH offers you the possibility to purchase the broad portfolio of click reagents, various kits for EdU-based cell proliferation assays and numerous other applications from the well-known brand baseclick. This enables us to offer you a necessary and comprehensive assortment for click chemistry.


Certificates of Analysis

You can search for and download your certificate of analysis for the selected product here. Please provide your batch number.
The following analysis certificates have been found:

Type analysis

Appearancewhite powder
Assay (HPLC)≥98 %