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Guanidine thiocyanate, 500 g

≥99 %, for biochemistry
Examples of effect: Damage metals and burn body tissues; may cause serious eye damage. Safety: Avoid contact; wear safety spectacles and gloves. In the event of contact with eyes and skin, rinse with water.
Examples of effect: Lead to damage to heath, cause irritation to eyes, skin or respiratory organs. Are fatal in larger quantities. Safety: As previously stated, in the event of skin irritation or contact with eyes, rinse with water or a suitable medium.
Danger
H302+H312+H332-H314-H412-EUH032
i harmful if swallowed, in contact with skin or if inhaled, causes severe skin burns and eye damage, harmful to aquatic life with long lasting effects
P260 P270 P280 P302+P352 P305+P351+P338 P310
i do not breathe dust, do not eat, drink or smoke when using this product, wear protective gloves/eye protection, IF ON SKIN: Wash with plenty of water, IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing, immediately call a POISON CENTER/doctor
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Guanidinium thiocyanate, Guanidinium isothiocyanate, GTC
Empirical formula C2H6N4S
Molar mass (M) 118,16 g/mol
Density (D) 1,29 g/cm³
Melting point (mp) 121 °C
ADR 8 II
WGK 2
CAS No. 593-84-0
EG-Nr. 209-812-1
UN-Nr. 1759

Reagent for denaturation of proteins and for isolation of DNA and RNA.
For a 4 M solution, solubilise 472,64 g in distilled water and fill to 1 l.

Stock solution: 4 M or 8 M in water. Storage of stock solution: +4 °C. Working concentration: 4 M in hydrous buffer system (e.g. 25 mM sodium citrate, 0,5 % SDS)

Highly chaotropic agent that potently destroys the three-dimensional structure of proteins, leading to denaturation. Guanidinium (iso)thiocyanate contains potent anionic as well as cationic groups, that form strong hydrogen bonds. It, therefore, can be used to break protein disulfide bonds as well as to disrupt hydrophobic interactions, and is added during RNA extraction in order to inhibit RNAse activity.
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Product details



Guanidine thiocyanate ≥99 %, for biochemistry

Highly chaotropic agent that potently destroys the three-dimensional structure of proteins, leading to denaturation. Guanidinium (iso)thiocyanate contains potent anionic as well as cationic groups, that form strong hydrogen bonds. It, therefore, can be used to break protein disulfide bonds as well as to disrupt hydrophobic interactions, and is added during RNA extraction in order to inhibit RNAse activity.



Guanidine thiocyanate
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Certificates of Analysis

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The following analysis certificates have been found:

Type analysis

Appearancecolourless crystals
Appearance (33 %, water)colourless, clear
Assay≥99.0 %
Melting point118-121 °C
Water≤0.3 %
Iron (Fe)≤0.0001 %
Heavy metals≤0.001 %
pH value (1 M, H2O)5.0-7.0
Absorbance
280 nm≤0.40
300 nm≤0.05