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Novobiocin sodium salt, 10 g

≥850 μg/mg, for biochemistry
Examples of effect: Lead to damage to heath, cause irritation to eyes, skin or respiratory organs. Are fatal in larger quantities. Safety: As previously stated, in the event of skin irritation or contact with eyes, rinse with water or a suitable medium.
Warning
H317-H319
i may cause an allergic skin reaction, causes serious eye irritation
P280 P302+P352 P305+P351+P338 P337+P313
i wear protective gloves/eye protection, IF ON SKIN: Wash with plenty of water, IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing, if eye irritation persists: Get medical advice/attention
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Empirical formula C31H35N2NaO11
Molar mass (M) 634,62 g/mol
Melting point (mp) 220 °C
Storage temp. +4 °C
WGK 1
CAS No. [1476-53-5]
EG-Nr. 216-023-6

Bacteriostatic antibiotic, HSP90 inhibitor.
Application: Stock solution: 100 mg/ml in H2O. Storage of stock solution: -20 °C. Working concentration: variable

Reduces growth of gram-positive bacteria by inhibition of initiation of DNA-synthesis via binding to ATP-binding sites of gyrase and topoisomerase. Novobiocin also interacts with the C-terminal ATP-binding site of HSP90, hence inhibiting its Chaperon quality. Also well suited as additive to microbiological nutrient media. Adding 40 mg/l Novobiocin during selective detection of coliform bacteria on Brilliant Green Bile broth (Art. No. CL06.1) efficiently reduces the growth of attendant flora (Alcaide et al., 1982, J. Appl. Bact. 53:143-6).
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€181.70/Pack Qty. 

excl. VAT. | 10 g per Pack Qty.

Art. No. 0247.3

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Product details



Novobiocin sodium salt ≥850 μg/mg, for biochemistry

Reduces growth of gram-positive bacteria by inhibition of initiation of DNA-synthesis via binding to ATP-binding sites of gyrase and topoisomerase. Novobiocin also interacts with the C-terminal ATP-binding site of HSP90, hence inhibiting its Chaperon quality. Also well suited as additive to microbiological nutrient media. Adding 40 mg/l Novobiocin during selective detection of coliform bacteria on Brilliant Green Bile broth (Art. No. CL06.1) efficiently reduces the growth of attendant flora (Alcaide et al., 1982, J. Appl. Bact. 53:143-6).



Novobiocin sodium salt
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The following analysis certificates have been found:

Type analysis

Activity≥850 µg/mg
Specific rotation [α]a (dry substance)-58° to -50°
pH value (2,5 % in H2O)6,5-8,5
Sulphated ash≤12,0 %
Water≤6,0 %

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