Technical Data Sheet
5-Ethynyl-2'-deoxyuridine (EdU), 100 mg
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Molar mass (M) 252,23 g/mol
Storage temp. -20 °C
Transport temp. cooled
WGK 3
CAS No. 61135-33-9
5-Ethynyl-2’-deoxyuridine (5-EdU) is a nucleoside analog to thymidine and can be incorporated into DNA during DNA synthesis (see also our EdU cell proliferation assays for more information). The newly synthesized DNA carries an alkyne moiety that can be easily clicked to azides to assess cell proliferation, cell cycles, viability, etc.
€123.65/Pack Qty.
excl. VAT. | 100 mg per Pack Qty.
Art. No. 7845.4
- Subtotal: 0.00
| Art. No. | Pack Qty. | Pack. | Price | Quantity | |
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| 7845.1 | 5 mg | plastic |
€26.80 |
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| 7845.3 | 50 mg | plastic |
€81.60 |
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| 7845.4 | 100 mg | plastic |
€123.65 |
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| 7845.5 | 500 mg | plastic |
€430.00 |
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| 7845.6 | 1 g | plastic |
€661.15 |
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Downloads / MSDS
General information
The copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) is the most prominent example of a group of reactions named click reactions. According to Sharpless’ definition, these reactions are characterised by high yields, mild reaction conditions, and by their tolerance of a broad range of functional groups.[1-3] Typically, the reactions require simple or no workup or purification of the product. The most important characteristic of the CuAAC reaction is its unique bioorthogonality as neither azide nor terminal alkyne functional groups are generally present in natural systems.
References:
1 H. C. Kolb, M.G. Finn, K. B. Sharpless, Angew. Chem. Int. Ed. 2001, 40, 2004-2021.
2 C.W. Tornoe, C. Christensen, M. Meldal, J. Org. Chem. 2002, 67, 3057-3064.
3 V. V. Rostovtsev, L. G. Green, V. V. Fokin, K. B. Sharpless, Angew. Chem. 2002, 114, 2708-2711; Angew. Chem. Int. Ed. 2002, 41, 2596-2599.
In recent years, click chemistry has become increasingly important and steadily more popular in research and development. The reasons for this are not only the easy handling and the high yields but also the countless application possibilities. Carl ROTH offers you the possibility to purchase the broad portfolio of click reagents, various kits for EdU-based cell proliferation assays and numerous other applications from the well-known brand baseclick. This enables us to offer you a necessary and comprehensive assortment for click chemistry.
Nucleosides
The detection of cell proliferation is of utmost importance for monitoring cell vitality, determining genotoxicity or evaluating anticancer drugs. The feeding of cells with EdU (5-Ethynyl-2'-deoxyuridine) or EU (5-Ethynyl uridine) can be used in cell proliferation studies.
Certificates of Analysis
Type analysis
| Appearance | white to off-white solid |
| Assay (HPLC) | ≥98 % |