NHS-PEG4-Azide, 100 mg
Molar mass (M) 388,37 g/mol
Density (D) 1 g/cm³
Storage temp. -20 °C
Transport temp. cooled
CAS No. [944251-24-5]
excl. VAT. | 100 mg per Pack Qty.
Art. No. 7823.4
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PEGylation and Linker
Click chemistry opens the door to introduce polyethylene glycols (PEGs) or other linkers in very sophisticated manner into your sample, which are still active for following reaction by the means of amine, carboxyl, malemide or NHS-functional terminal groups. You can choose between alkyne and azide structured PEGs and linkers which you find in the table below.
The copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) is the most prominent example of a group of reactions named click reactions. According to Sharpless’ definition, these reactions are characterised by high yields, mild reaction conditions, and by their tolerance of a broad range of functional groups.[1-3] Typically, the reactions require simple or no workup or purification of the product. The most important characteristic of the CuAAC reaction is its unique bioorthogonality as neither azide nor terminal alkyne functional groups are generally present in natural systems.
1 H. C. Kolb, M.G. Finn, K. B. Sharpless, Angew. Chem. Int. Ed. 2001, 40, 2004-2021.
2 C.W. Tornoe, C. Christensen, M. Meldal, J. Org. Chem. 2002, 67, 3057-3064.
3 V. V. Rostovtsev, L. G. Green, V. V. Fokin, K. B. Sharpless, Angew. Chem. 2002, 114, 2708-2711; Angew. Chem. Int. Ed. 2002, 41, 2596-2599.
|Appearance||colourless viscous liquid|
|Assay (NMR)||≥90 %|
|Solubility||DMSO, DMF, CH2Cl2|