Geldanamycin, 5 mg
Molar mass (M) 560,64 g/mol
Melting point (mp) 275 °C
Storage temp. -20 °C
Transport temp. ambient temp.
CAS No. [30562-34-6]
Application: Stock solution: 1000x in DMSO or methanol. Storage of stock solution at -20 °C, max. 2 weeks at 4 °C. Working concentration: 1-10 µg/ml. Photo sensitive! Store protected from light.
excl. VAT. | 5 mg per Pack Qty.
Art. No. HN71.2
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Geldanamycin ≥98 %, for biochemistry
The specific binding of geldanamycin to heat shock protein 90 (HSP90) and its ER homologue GP96 leads to inhibition of the chaperone, results in degradation of Hsp90 substrates and, subsequently, to deregulation of central cell mechanisms - cell cycle, cell proliferation, apoptosis/cell vitality. Geldanamycin arrests cells in G2 phase, thus interfering with angiogenesis and oncogenesis. Due to its antitumor potential it may be used as antibiotic against several eucaryotic carcinogenic cell lines. Additionally, geldanamycin is used as inhibitor of tyrosin-kinase and during analysis of several other physiological regulatory mechanisms.
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|Assay (HPLC)||≥98 %|
|λ max.||259 nm, 307 nm|
|Melting point||258-262 °C|