Geldanamycin

≥98 %, for biochemistry
HSP90 inhibitor, tyrosine kinase inhibitor. Benzoquinone ansamycin antibiotic. Binds specifically to the heat shock protein HSP90.

Geldanamycin
Empirical formula C29H40N2O9
Molar mass (M) 560,64 g/mol
Melting point (mp)260-275 °C
Storage temp.: -20 °C
Transport temp.: room temp.
WGK 1
CAS No.[30562-34-6]

The specific binding of geldanamycin to heat shock protein 90 (HSP90) and its ER homologue GP96 leads to inhibition of the chaperone, results in degradation of Hsp90 substrates and, subsequently, to deregulation of central cell mechanisms - cell cycle, cell proliferation, apoptosis/cell vitality. Geldanamycin arrests cells in G2 phase, thus interfering with angiogenesis and oncogenesis. Due to its antitumor potential it may be used as antibiotic against several eucaryotic carcinogenic cell lines. Additionally, geldanamycin is used as inhibitor of tyrosin-kinase and during analysis of several other physiological regulatory mechanisms.

Application:

Stock solution: 1000x in DMSO or methanol

Storage of stock solution at -20 °C, max. 2 weeks at 4 °C

Working concentration: 1-10 µg/ml

Photo sensitive! Store protected from light.


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Geldanamycin

Status Art. No. Pack Qty. Packaging Price Quantity Action
Item available in stock HN71.1 1 mg glass €69.80
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Item available in stock HN71.2 5 mg glass €171.50
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Item available in stock HN71.3 10 mg glass €247.15
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Technical information

Type analysis:
Assay (HPLC)≥98 %
λ max.259 nm, 307 nm
Melting point258-262 °C

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