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Geldanamycin, 1 mg

≥98 %, for biochemistry
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Empirical formula C29H40N2O9
Molar mass (M) 560,64 g/mol
Melting point (mp) 275 °C
Storage temp. -20 °C
Transport temp. ambient temp.
WGK 1
CAS No. [30562-34-6]

HSP90 inhibitor, tyrosine kinase inhibitor. Benzoquinone ansamycin antibiotic. Binds specifically to the heat shock protein HSP90.
Application: Stock solution: 1000x in DMSO or methanol. Storage of stock solution at -20 °C, max. 2 weeks at 4 °C. Working concentration: 1-10 µg/ml. Photo sensitive! Store protected from light.

The specific binding of geldanamycin to heat shock protein 90 (HSP90) and its ER homologue GP96 lead ...
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Type analysis

€72.60/Pack Qty. 

excl. VAT. | 1 mg per Pack Qty.

Art. No. HN71.1

Available at short notice
from 6 Pack Qty. €68.97/Pack Qty.
from 24 Pack Qty. €65.34/Pack Qty.
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Geldanamycin ≥98 %, for biochemistry

The specific binding of geldanamycin to heat shock protein 90 (HSP90) and its ER homologue GP96 leads to inhibition of the chaperone, results in degradation of Hsp90 substrates and, subsequently, to deregulation of central cell mechanisms - cell cycle, cell proliferation, apoptosis/cell vitality. Geldanamycin arrests cells in G2 phase, thus interfering with angiogenesis and oncogenesis. Due to its antitumor potential it may be used as antibiotic against several eucaryotic carcinogenic cell lines. Additionally, geldanamycin is used as inhibitor of tyrosin-kinase and during analysis of several other physiological regulatory mechanisms.



Geldanamycin
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Order No. Pack Qty. Pack. Price Quantity
HN71.1 1 mg glass €72.60
HN71.2 5 mg glass €178.35
HN71.3 10 mg glass €256.95
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Certificates of Analysis

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The following analysis certificates have been found:

Type analysis

Assay (HPLC)≥98 %  
λ max.259 nm, 307 nm  
Melting point258-262 °C  

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