Biotin-PEG4-Alkyne, 1 mg
Molar mass (M) 457,58 g/mol
Storage temp. -20 °C
Transport temp. cooled
CAS No. [1458576-00-5]
excl. VAT. | 1 mg per Pack Qty.
Art. No. 7805.1
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The copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) is the most prominent example of a group of reactions named click reactions. According to Sharpless’ definition, these reactions are characterised by high yields, mild reaction conditions, and by their tolerance of a broad range of functional groups.[1-3] Typically, the reactions require simple or no workup or purification of the product. The most important characteristic of the CuAAC reaction is its unique bioorthogonality as neither azide nor terminal alkyne functional groups are generally present in natural systems.
1 H. C. Kolb, M.G. Finn, K. B. Sharpless, Angew. Chem. Int. Ed. 2001, 40, 2004-2021.
2 C.W. Tornoe, C. Christensen, M. Meldal, J. Org. Chem. 2002, 67, 3057-3064.
3 V. V. Rostovtsev, L. G. Green, V. V. Fokin, K. B. Sharpless, Angew. Chem. 2002, 114, 2708-2711; Angew. Chem. Int. Ed. 2002, 41, 2596-2599.
Besides fluorescent tags other non-fluorescent labels play an important role in biochemistry and microbiology. Incorporation of such functional groups into your sample with high yields and selectivity is easily possible by click chemistry. Further, the click reaction is compatible with or rather orthogonal to various other labelling methodologies. In order to enlarge the scope for your personalised application we offer these tags in azide and alkyne functional form.
|Assay (NMR)||≥95 %|
|Solubility||DMSO, DMF, CH2Cl2, CHCl3, MeOH|