Tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA), 10 mg
Molar mass (M) 530,63 g/mol
Melting point (mp) 147 °C
Storage temp. -20 °C
Transport temp. cooled
CAS No. [510758-28-8]
excl. VAT. | 10 mg per Pack Qty.
Art. No. 7814.2
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The copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) is the most prominent example of a group of reactions named click reactions. According to Sharpless’ definition, these reactions are characterised by high yields, mild reaction conditions, and by their tolerance of a broad range of functional groups.[1-3] Typically, the reactions require simple or no workup or purification of the product. The most important characteristic of the CuAAC reaction is its unique bioorthogonality as neither azide nor terminal alkyne functional groups are generally present in natural systems.
1 H. C. Kolb, M.G. Finn, K. B. Sharpless, Angew. Chem. Int. Ed. 2001, 40, 2004-2021.
2 C.W. Tornoe, C. Christensen, M. Meldal, J. Org. Chem. 2002, 67, 3057-3064.
3 V. V. Rostovtsev, L. G. Green, V. V. Fokin, K. B. Sharpless, Angew. Chem. 2002, 114, 2708-2711; Angew. Chem. Int. Ed. 2002, 41, 2596-2599.
TBTA (Art.No. 7814) is suitable as copper-stabilising ligand for reactions in organic solvents. THPTA (Art.No. 7822) on the other hand is an optimal ligand for reactions in aqueous media.
Starting from diverse copper catalyst sources, over Cu(I) stabilising ligands to buffer additives and solvents, you will find all necessary reagents in the special ROTI®Click quality to perform your click reactions here.
|Appearance||white to tan powder|
|Assay (HPLC)||≥95 %|
|Alkyne- and Azide-free||complies|