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Geneticin disulphate (G418 Sulphate), 1 g

≥650 U/mg, for biochemistry
Examples of effect: Have an allergenic effect, carcinogenic, mutagenic, toxic to reproduction and cause developmental toxicity (reprotoxic) or damage to organs Safety: You must be well-informed before starting work with these substances; wear protective clothing and gloves, eye protection and mask or breathing protection.
Danger
H317-H334
i may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled
P260 P302+P352 P342+P311
i do not breathe dust, IF ON SKIN: Wash with plenty of water, if experiencing respiratory symptoms: Call a POISON CENTER/doctor
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Antibiotic G 418
Empirical formula C20H40N4O10 · 2 H2SO4
Molar mass (M) 692,70 g/mol
Melting point (mp) 139 °C
Storage temp. +4 °C
WGK 1
CAS No. 108321-42-2

Aminoglycoside antibiotic
Stock solution: 10-50 mg/ml in H2O or culture medium.
Storage of stock solution: -20 °C.
Working concentration: 50-1000 µg/ml, has to be established for each cell type.

Inhibits protein biosynthesis by binding to ribosomes, particularly to eukaryotic 80S ribosomes. Through interference with the tRNA docking process, sequence errors appear and the elongating peptide chain is truncated. Geneticin disulphate unspecifically effects all cells, and is highly toxic for eukaryotic cells. Resistance is mediated by the bacterial enzyme aminoglycoside-3-phosphotransferase.
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€110.20/Pack Qty. 

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Art. No. 0239.3

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Product details



Geneticin disulphate (G418 Sulphate) ≥650 U/mg, for biochemistry

Inhibits protein biosynthesis by binding to ribosomes, particularly to eukaryotic 80S ribosomes. Through interference with the tRNA docking process, sequence errors appear and the elongating peptide chain is truncated. Geneticin disulphate unspecifically effects all cells, and is highly toxic for eukaryotic cells. Resistance is mediated by the bacterial enzyme aminoglycoside-3-phosphotransferase.


Application: Selection of transfected eukaryotic cells.
Resistance gene: Neomycin.



Geneticin disulphate (G418 Sulphate)
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0239.1 250 mg glass

€44.00

0239.2 500 mg glass

€62.25

0239.3 1 g glass

€110.20

0239.4 10 g glass

€772.95

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Type analysis

Activity≥650 U/mg
Water (KF)≤12 %